The factors of the regional economic integration and the product manufacturing networking make the cross-regional logistics distribution activities become normal. Based on the design problem of distribution nelwork,this paper considers the characteristics of the multiple vehicle types,and proposes the design problem of muli-level logistics distribution network considering the multiple vehicles types and a mixed integer programming model. The results show thal the Iransportation cost in the first slage accounts for a higher proportion of the total lransportation cost in the multi-level logistics distribution network and is more sensitive to the unit transportation cost.When the demand of the customer is large,the sufficient vehicles of the first type can reduce the total transportation cost.