Abstract: Brushite/gypsum core-shell composite spherical particles were prepared by agitating spray dr-ying method using brushite and a-calcium sulfate as raw materials, and then gelatin was mixed with theprepared spherical particles and collected by stacking in a mold. In the method, a gelatin/brushite/gypsum composite porous biological scaffold was finally prepared. The composition , morphology and structur-al characteristics of the prepared composite porous seaffolds were characterized by XRD and SEM. Its internal structure, composition and morphology were studied and analyzed, and its external degradabilitand mechanical properties were analyzed. The results show that the gelatin/brushite/gypsum compositeporous scaffold has a certain pore structure, and the average porosity is 61% , which can meet the re-quirements of the bone tissue engineering for the sealfold material; the composite porous scaffold has goodcompressive strength and average resistance. The compressive strength is (6. 1 ±0. 05)MPa, the com-posite porous seaffold has no cytotoxicity, and the in vitro degradation in SBF solution cyele is about 80days. This material has a broad prspect in bone tissue repair.

Key words: calcium hydrogen phosphate dihydrate, bone tissue, porous scaffold