The school-running quality is the key element for higher vocational colleges to survive and developin intense competition. Taking 12 professional higher vocational colleges with different industries as examples,this paper analyzes the five differences concerning enrollment, sponsorship, assets,major setup, majors for enrollment&faculty of the colleges. Then it makes a contrastive study of the school-running qualities and explores the connection and difference among colleges in order to improve the school-running qualities of professional higher vocational colleges.