Abstract: The sorting position of the existing medicine retail distribution center(DC)is usually partiboned according to the storage type and storage condition of medicine，and the adjustment period of sorstorage is long in the same area，which affects the efficiency of sorting.  Based on Apriori association
algorithm and combined with the classification principle of ABC，A method of dynamic setting for sorting and reserving is proposed in this paper.  The method can greatly improve the sorting movement line，reduce the sorting distance，and improve sorting efficiency.

Key words: Apriori association algorithm, picking and sorting slots dynamic design, pharmaceutical retail distribution